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Conversations with billionaires, unicorn founders, and funders.
Hosted by Sarah Chen-Spellings, Billion Dollar Moves examines how enduring companies — and the capital behind them — are built. Filmed live across global innovation hubs—from Silicon Valley to Singapore—it’s where capital meets conviction, and the conversations catalyze action.
Trusted by governments, family offices, and institutional investors, Billion Dollar Moves doesn’t just talk about the future—it helps build it.
Conversations with billionaires, unicorn founders, and the world’s leading funders.
Hosted by Sarah Chen-Spellings, a global investor and entrepreneur, Billion Dollar Moves examines how enduring companies — and the capital behind them — are built.
Through long-form conversations, the show explores decision-making under uncertainty, capital allocation, and the inflection points that shape category-defining businesses. From early platform backstories to allocator frameworks used across private markets, the focus is on judgment, incentives, and long-term value creation — beyond headlines and hype.
New episodes weekly.
Built for those who take the long view.
Billion Dollar Moves is proud to be part of the Hubspot Podcast Network with 10 million downloads a month as a group.
In this episode of Billion Dollar Moves, I sit down with David Berry, Co-Founder and Managing Partner of Averin Capital, for a conversation about building billion-dollar breakthroughs in healthcare.
David has founded more than 30 companies, including seven valued over $1B, and has helped shape companies across biotech, AI drug discovery, microbiome therapeutics, agriculture, and health infrastructure.
From losing a childhood friend to brain cancer, to asking why the hardest problems are worth pursuing, David shares how mission, science, and capital come together to create venture-scale healthcare companies.
For founders, funders, and family offices investing in the future of health, this is a conversation about conviction, ethics, and building for impact at scale.
Watch the full conversation and subscribe for more discussions at the intersection of capital, governance, and long-term wealth.
00:00 – Intro: Why go after the biggest problems?
01:12 – Truth vs. belief in science
03:00 – The myth that humans only use 10% of their brains
04:28 – Rethinking cancer and inherited assumptions
05:38 – How big ideas emerge from questioning “truth”
06:30 – Entrepreneur vs. investor: The N of one
08:10 – Building Seres Therapeutics and the microbiome frontier
11:00 – Turning strange science into a venture-scale company
12:20 – Why drug development does not always have to take 10–15 years
14:10 – Valo Health and AI-powered drug discovery
17:15 – Product-investor fit in biotech
20:30 – Why companies fail: Teams, resilience, and near-death moments
22:15 – Averin Capital and the transformation of health through technology
23:20 – BioLink and the future of continuous health monitoring
26:00 – Ozempic, access, and ethics in healthcare
31:10 – Women’s health, clinical trials, and bias in medical data
35:00 – David’s vision for Averin Capital
39:00 – How family offices should think about investing in health
40:00 – The next billion-dollar moves in healthcare
40:35 – Rapid fire
About David Berry
David is Co-Founder and Managing Partner at Averin. As an innovator and a company builder, he has been driven by the power of technology to transform industries. David has been a founder of over 30 companies, including 7 that have been valued at over $1B.
David was previously a General Partner at Flagship Pioneering. He was also founder and CEO of Valo Health, where he raised over $500M and executed a transformative partnership with Novo Nordisk.
David received his M.D. from Harvard Medical School and his Ph.D. from MIT through the biological engineering division, where he worked with Professors Robert Langer and Ram Sasisekharan. David works closely with Biolinq amongst other Averin companies.
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Billion Dollar Moves Podcast | The Top Global Venture & Business Podcast for Founders & Funders | Backed by HubSpot Podcast Network
Conversations with billionaires, unicorn founders, and the world’s leading funders.
Hosted by Sarah Chen-Spellings, Billion Dollar Moves examines how enduring companies — and the capital behind them — are built.
Through long-form conversations, the show explores decision-making under uncertainty, capital allocation, and the inflection points that shape category-defining businesses. From early platform backstories to allocator frameworks used across private markets, the focus is on judgment, incentives, and long-term value creation — beyond headlines and hype.
New episodes weekly.
Built for those who take the long view.
PODCAST INFO:
Podcast website: https://billiondollarmoves.com
Watch on Youtube: https://tinyurl.com/sarahchenglobal
Join the community: https://sarah-chen.ck.page/billiondollarmoves
FOLLOW SARAH:
https://linkedin.com/in/sarahchenglobal
https://instagram.com/sarahchenglobal
https://x.com/sarahchenglobal
In venture, every move can make—or break—a billion-dollar outcome.
Panu Maulaheimo
- "We've worked with Sarah & her team to promote investing in and from Helsinki, leveraging ad spots and a sponsored series of episodes showcasing our nation's best unicorn founders and funders. Sarah's compelling storytelling combined with her targeted reach has resulted in an oversubscribed program for international investors. This was our second year working with her, and we are excited to continue working with her."
Monsha’at
- "Sarah Chen-Spellings brought her signature energy and commanding presence to Biban 2024, making her the ideal host and moderator alongside the Shark, Robert Herjavec. Her deep insights into investing in innovation and women-led ventures resonated powerfully with our audience of entrepreneurs, business leaders, and global investors. With her polished media expertise and natural ability to engage across cultures, she elevated the event, ensuring impactful takeaways and amplifying our reach across platforms. We were honored to have a globally renowned name join our stage, and we are excited to continue to work with her to drive entrepreneurship in our country and beyond."
Ann Cairns
- "We at Mastercard are delighted to be working with Beyond the Billion to address the massive gender venture funding gap holding women innovators back. Too much of our world was designed without women in mind and without women involved. Shelly, Sarah, and their team have done an excellent job of raising awareness about this issue and creating a network of VCs pledged to do more by investing in female-founded startups to address the problem. Working with our team, they seamlessly created an impactful dialogue based on Mastercard's gender balance narrative."
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This show is about unfiltered conversations about success, failure, fear and courage, in the pursuit of the next big thing in tech and venture.
From boardroom power plays to investor backchannels, you’ll hear the untold stories behind iconic companies like YouTube, Canva, and Vimeo, and go inside the minds of those moving capital at firms like Sequoia, Lightspeed, and beyond.
Whether you’re chasing your first $10M—or your next billion—this show is your front-row seat to how the smartest founders and funders win. Think raw, unfiltered, no-BS insight—designed to help you move faster, smarter, and bolder.
This isn’t just another business podcast. This is your billion-dollar playbook.
Your front-row seat to how the smartest founders and funders win. Think raw, unfiltered,no-BS insight—designed to help you move faster, smarter, and bolder.
Disclaimer
This podcast is an expression of personal opinion and does not represent the opinion of the host Sarah Chen-Spellings (SCS) as an investor personally, her firm Beyond The Billion (BTB) or any company discussed. These discussions are for informational purposes only, including any mention of securities or venture funds; and does not constitute any investment, legal, tax advice. SCS or BTB may hold currently, or in the future, direct or indirect interests in the featured companies or funds. No guarantee of any kind is implied or possible where projections of future conditions are attempted.